Abstract :The development of Squamous Cell Carcinoma (SCC) is a severe complication of chronic Hidradenitis Suppurativa (HS). Male patients with prolonged HS in extra-axillary areas are especially at risk of this complication. The case in our paper of HS associated with vulvar SCC emphasizes that women can also develop this complication. In addition to lichen sclerosus vulvae (via dVIN) and high risk HPV (via uVIN) there is a third disease that can lead to vulvar cancer, namely chronic HS. The clinician should look out for a malignant transformation in the presence of severe, chronic HS, and have a low threshold for biopsy. Staging, therapy and follow-up should be performed by gynecologic oncologists.